Actor and Activist, Alyssa Milano

Podcast Episode
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Isaac Mizrahi chats with humanitarian and New York Times bestselling author, Alyssa Milano, about the moment that changed her life when she was 15, why she’s sworn off Botox and fillers, the most terrifying thing she’s ever done and so much much more.Follow Hello Isaac on @helloisaacpodcast on Instagram and TikTok, Isaac @imisaacmizrahi on Instagram and TikTok and Alyssa Milano @milano_alyssa.(Recorded on January 18, 2024)See omnystudio.com/listener for privacy information.
Featuring
Actor and Activist, Alyssa Milano
Podcast Episode · Jun 20, 2026 · omny.fm
Actor and Activist, Alyssa Milano

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Takeaways (10) View 14 quotes

Alyssa Milano inspired by Alyssa Milano · Feb 2024

Motherhood is the most terrifying thing I've ever done, and I fail at it multiple times a day.

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Alyssa Milano inspired by Alyssa Milano · Feb 2024

During COVID, I felt relief — everyone else's panic finally matched how I normally am inside.

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Alyssa Milano inspired by Alyssa Milano · Feb 2024

I want mental health care to be as routine for my kids as going to the dentist.

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Alyssa Milano inspired by Alyssa Milano · Feb 2024

Raising my first child also meant working through what the little girl inside me never got to resolve.

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Alyssa Milano inspired by Alyssa Milano · Feb 2024

I stopped Botox because I didn't look younger — I just looked like I was doing stuff to my face.

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Alyssa Milano inspired by Alyssa Milano · Feb 2024

Using my fame to kiss Ryan White on TV at 15 — to prove you couldn't get HIV from casual contact — changed what work meant to me.

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Alyssa Milano inspired by Alyssa Milano · Feb 2024

Activism is 98% failure, so I've stopped being attached to outcomes and just commit to the process.

Alyssa Milano inspired by Alyssa Milano · Feb 2024

Being publicly vocal about my own abortions was a choice — having it used against my kids is a different thing entirely.

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Alyssa Milano inspired by Alyssa Milano · Feb 2024

Humanity wouldn't keep going if people weren't hardwired to hope for something better.

Alyssa Milano inspired by Alyssa Milano · Feb 2024

Having dyslexia meant being tutored on set was probably the best education I could have gotten.

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Quotes (14)

“I don't think anyone doesn't struggle with motherhood. I think it is the most horrifying, terrifying thing I have ever done in my life, and I fail at it multiple times a day. But I'm committed to it, and I feel like it's what you put into i...” “I don't think anyone doesn't struggle with motherhood. I think it is the most horrifying, terrifying thing I have ever done in my life, and I fail at it multiple times a day. But I'm committed to it, and I feel like it's what you put into it, what you get out of it. But yeah. I mean, I had such bad anxiety after Milo. I mean, you remember? There were days that I would come into work, and I'd be like, I was in the hospital last night with a panic attack. And that was all about motherhood.”
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“I had such bad anxiety after Milo. I remember this feeling of, like, why am I thriving right now? And I realized it was because everybody else was in this state of total hysteria. And it matched how I normally am. And so I could look at peo...” “I had such bad anxiety after Milo. I remember this feeling of, like, why am I thriving right now? And I realized it was because everybody else was in this state of total hysteria. And it matched how I normally am. And so I could look at people and go like, I know. I felt the same. Right? Like, see? I told you everything's fucked. Now you believe me.”
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“I have to give so much credit to my family and my support system who consistently and always reminded me what was important in life and what the responsibility was to be a public figure.”
“I was diagnosed with dyslexia. So I don't know that being in a normal school would have actually been okay for me. I think that being tutored on a set enabled me to have the best education I probably could have ever had or dreamed of becaus...” “I was diagnosed with dyslexia. So I don't know that being in a normal school would have actually been okay for me. I think that being tutored on a set enabled me to have the best education I probably could have ever had or dreamed of because of my learning difference.”
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“I wanted mental health to be as important as and as common as going to the dentist for them. We have someone that we talk to as a family. I call them the feelings doctor. And I think it's really important that for me and my history of anxie...” “I wanted mental health to be as important as and as common as going to the dentist for them. We have someone that we talk to as a family. I call them the feelings doctor. And I think it's really important that for me and my history of anxiety, that my kids are raised with this idea that if you're gonna go to the dentist, if you're gonna take care of all of your vaccinations, and if you're gonna take care of your heart, then you also have to take care of your mind.”
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“I just got to this point where I realized that so much of beauty and womanhood was about feeding on insecurities. And I felt like if I was going to be okay with aging, because guess what? It's all happening to everyone. I was going to have...” “I just got to this point where I realized that so much of beauty and womanhood was about feeding on insecurities. And I felt like if I was going to be okay with aging, because guess what? It's all happening to everyone. I was going to have to not try to look like I'm not aging. And believe me, I did, like, the Botox and the filler and all. I haven't done anything in two and a half years because I just felt like I didn't look like I was younger. I looked like I was just doing shit to my face.”
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“I think when you have your first child, you're healing the little child inside of you at the same time you're raising this child that is outside of you. And I think it became for me that my own childhood insecurities, I was projecting onto...” “I think when you have your first child, you're healing the little child inside of you at the same time you're raising this child that is outside of you. And I think it became for me that my own childhood insecurities, I was projecting onto my children. And so I needed to heal the little girl inside of me so that I could let that go and just really have a foundation to build on for my children.”
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“Feeling othered. Going through puberty on TV in front of millions of people. Because again, at that time, there were only three stations. So when you were a top 10 show, it meant there were, you know, 30,000,000 people watching you. And I h...” “Feeling othered. Going through puberty on TV in front of millions of people. Because again, at that time, there were only three stations. So when you were a top 10 show, it meant there were, you know, 30,000,000 people watching you. And I have childhood sexual trauma. And so having that, then raising a little girl who is my mini me and who every time I look at her, especially at this age, I am reminded of that trauma.”
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“For me and my own insecurities, it was not going to be beneficial for me to be chasing away to look. It was probably going to lead to more anxiety or depression or insecurity.”
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“I've been very vocal about having abortions because we saw this writing on the wall when Trump was elected. So I wanted to use my own experience with needing health care as a way to allow women to speak up and to fight against what we all s...” “I've been very vocal about having abortions because we saw this writing on the wall when Trump was elected. So I wanted to use my own experience with needing health care as a way to allow women to speak up and to fight against what we all saw was gonna happen. It wound up happening anyway. To have that part of my past be used against me and for people to not think about what that might do to my kids, yeah, it hurts.”
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“Being an activist is 98% failure. There are so few wins in the fight for justice and equality and equity. You can't be attached to the outcome, it's gotta be about the process. And I have taken that little thing that I have learned from bei...” “Being an activist is 98% failure. There are so few wins in the fight for justice and equality and equity. You can't be attached to the outcome, it's gotta be about the process. And I have taken that little thing that I have learned from being an activist, and I've put it towards everything that I do. Because if you think about you can't be attached to the outcome, you have to be committed to the process, it means everything. It's parenting. It's a business endeavor. It's painting for me. It's learning more. It's therapy. It's evolution.”
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“When I was 15 years old and on Who's the Boss, Elton John called me and told me about a boy named Ryan White who is HIV positive, who was thrown out of school and fought for the right to go back to school. And so I met him, and we became fr...” “When I was 15 years old and on Who's the Boss, Elton John called me and told me about a boy named Ryan White who is HIV positive, who was thrown out of school and fought for the right to go back to school. And so I met him, and we became friends. And I think what it was is because we connected because we were both othered. We were both made to feel like we were different and we weren't the same. And we became good friends, and through that friendship, he asked me if I would go on TV to kiss him to prove that you couldn't get HIV AIDS from casual contact. And I was 15, the height of Who's the Boss, and I did it. And that single moment where I was using my fame for something other than what I had seen other people use it for changed my life. It also changed the way in which I was motivated to continue working because it wasn't just about me. It was about continuing to have a voice so that I could impact positive change.”
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“I think that we are hardwired or prewired to have a certain level of hope. I think humanity would cease to exist if we didn't have hope for a brighter tomorrow. There is so much darkness, and there is so much pain, and there is so much stru...” “I think that we are hardwired or prewired to have a certain level of hope. I think humanity would cease to exist if we didn't have hope for a brighter tomorrow. There is so much darkness, and there is so much pain, and there is so much struggle. Why would anybody continue to keep going if there wasn't hope? And I feel like I have been blessed enough to be surrounded by people who have it super hard. I've witnessed the struggles of how bad humanity can be, but the thing that connects all of us is this ability to hope.”